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Fig. 3 | Genome Medicine

Fig. 3

From: NSAID use and somatic exomic mutations in Barrett’s esophagus

Fig. 3

Pathway mutations and diversity. a Pathways with significantly lower functional SNV/indel mutations in NSAID users vs non-users are plotted in columns, with pathways ordered left to right by total number of genes with functional mutations in each pathway. For each gene, the left plot displays a colored box in one or more pathways in which that gene is classified. Genes names are ordered from top to bottom by number of participants with at least one functional mutation in that gene, then by NSAID non-users, then users. The right plot shows the count of NSAID users (blue) and non-users (red) with at least one functional mutations in each gene. b Same plot organization as in (a) for genes with functional mutations in only NSAID user (blue) or in only non-user (red). Most genes had functional mutations in only one individual, highlighting the heterogeneity of mutated genes across participants. c NSAID use selects against diversity of mutations across pathways. The number of functional mutations per participant, per pathway, normalized by the number of genes per pathway, is shown for users (top heatmap) and non-users (bottom heat map)

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