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Fig. 2 | Genome Medicine

Fig. 2

From: NSAID use and somatic exomic mutations in Barrett’s esophagus

Fig. 2

Mutation signatures in NSAID users and non-users. a Deconvoluting the mutation profile across the cohort into stable signatures using the method of Alexandrov et al. [29] yields a two-signature solution comprising COSMIC S1 and S17. b DeconstructSigs, an independent method of determining COSMIC mutation signature contributions to per-individual mutation profiles, shows COSMIC S1 and S17 as dominant, with relative proportions sensitive to NSAID use and smoking status. The relative contribution of the top five signatures (which had ≥ 5% of the total mutations associated with them) to each patient category (pie charts) and to each patient (bar charts) is shown

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