Table 1 Emerging pathways in neuroimaging-genomics studies
From: Neuroimaging genomics in psychiatry—a translational approach
Neural phenotype | Clinical manifestations | Enriched pathways | Examples of studies that identified these associated pathways in humans |
|---|---|---|---|
Subcortical brain volumes | On average, hippocampal volumes are smaller in patients with depression [176], bipolar disorder [177], and schizophrenia [178] compared with healthy controls | • Neurodevelopment • Synaptic signaling • Ion transport and storage • Axonal transport • Neuronal apoptosis • Neural growth • Neural differentiation • Immune pathways | |
Brain connectivity | Brain white matter microstructure is disrupted globally in schizophrenia [179] | • ATP synthesis and metabolism • Axon guidance • Fasciculation during development | Fornito et al. 2015 [133] |
Vértes et al. 2016 [134] | |||
Transcriptional profiles | Transcription factor EGR1 significantly downregulated in brains of schizophrenic patients compared with controls [180] | • Ion channels • Synaptic activity • ATP metabolism | Wang et al. 2015 [136] |
Richiardi et al. 2015 [137] |