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Table 4 Impact of RAB10 over-expression and knockdown in N2A695 cells

From: Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience

  

p value

Fold change (± SEM)

RAB10 over-expression

Aβ40

0.0011

−0.5933 ± 0.1162

Aβ42

0.2008

0.3249 ± 0.3709

Aβ42/Aβ40

0.0133

2.014 ± 0.6894

sAPPalpha

0.3436

0.02252 ± 0.05198

sAPPbeta

0.0187

0.1466 ± 0.04776

sAPPtotal

0.3581

−0.01433 ± 0.03673

RAB10 knockdown

Aβ40

0.4095

−0.06635 ± 0.2825

Aβ42

0.0003

−0.4453 ± 0.08428

Aβ42/Aβ40

0.0001

−0.3876 ± 0.02243

sAPPalpha

0.2899

0.1131 ± 0.188

sAPPbeta

0.2025

0.2457 ± 0.2642

sAPPtotal

0.3233

0.1446 ± 0.2922

  1. The p value for the comparison to GFP control (over-expression) and scrambled shRNA (knockdown) and fold change for each amyloid measurement are provided