From: Strength of functional signature correlates with effect size in autism
Functional property | Spearman’s correlation | FDR |
---|---|---|
Gene essentiality (Georgi et al. [50]) | 0.95 | 0.001 |
GO:0048699 (generation of neurons) | 0.92 | 0.003 |
FMRP interactors (Darnell et al. [49]) | 0.91 | 0.003 |
Brainspan co-expression network | 0.90 | 0.003 |
SynapseSet (Lips et al. [46]) | 0.90 | 0.003 |
Haploinsufficiency scores | 0.89 | 0.003 |
RVIS | 0.86 | 0.007 |
GSE25219: Overall expression | 0.84 | 0.008 |
GO:0007409 (axonogenesis) | 0.84 | 0.006 |
GO:0030182 (neuron differentiation) | 0.84 | 0.006 |
GO:0048667 (cell morphogenesis involved in neuron differentiation) | 0.84 | 0.006 |
GO:0061564 (axon development) | 0.84 | 0.006 |
Chromatin remodeling gene set (Ronan et al. [48]) | 0.83 | 0.006 |
GSE25219: Fetal expression | 0.83 | 0.006 |