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Table 2 Functional properties with significant functional convergence trends

From: Strength of functional signature correlates with effect size in autism

Functional property

Spearman’s correlation

FDR

Gene essentiality (Georgi et al. [50])

0.95

0.001

GO:0048699 (generation of neurons)

0.92

0.003

FMRP interactors (Darnell et al. [49])

0.91

0.003

Brainspan co-expression network

0.90

0.003

SynapseSet (Lips et al. [46])

0.90

0.003

Haploinsufficiency scores

0.89

0.003

RVIS

0.86

0.007

GSE25219: Overall expression

0.84

0.008

GO:0007409 (axonogenesis)

0.84

0.006

GO:0030182 (neuron differentiation)

0.84

0.006

GO:0048667 (cell morphogenesis involved in neuron differentiation)

0.84

0.006

GO:0061564 (axon development)

0.84

0.006

Chromatin remodeling gene set (Ronan et al. [48])

0.83

0.006

GSE25219: Fetal expression

0.83

0.006