Fig. 3
From: GLADIATOR: a global approach for elucidating disease modules
The objective function guides detection of modules enriched with known disease-related proteins. As the annealing process minimizes the Euclidean distance between module similarity and phenotypic similarity, the disease modules become more enriched with disease-related proteins, measured by the –log hypergeometric p value between associations predicted by GLADIATOR’s modules and gold-standard associations retrieved from DisGeNET