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Fig. 4 | Genome Medicine

Fig. 4

From: Type 2 diabetes and obesity induce similar transcriptional reprogramming in human myocytes

Fig. 4

Reporter metabolite analysis of T2D. a Reporter metabolite analysis was run to identify metabolites significantly affected by differential expression. This analysis revealed a tightly connected subnetwork of metabolites participating in sphingolipid metabolism that is affected by transcriptional regulation in T2D. b An overview of the reactions that involve the identified metabolites. c The genes connected to each metabolite gene-set, together with their individual significance and fold change direction. Significantly differentially expressed genes (q < 0.05) in T2D versus controls are marked in bold and color. Ceramide (Cer), glucosylceramide (GluCer), lactosylceramide (LacCer), galactosylceramide (GalCer), digalactosylceramide (DiGalCer), UDP-galactose (UDP-Gal), UDP-glucose (UDP-Glu)

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