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Fig. 4 | Genome Medicine

Fig. 4

From: Activity of distinct growth factor receptor network components in breast tumors uncovers two biologically relevant subtypes

Fig. 4

Survival and growth phenotypes differ in cell survival mechanisms. a The heatmap represents scaled activation values across 20 breast cancer cell lines used in this analysis for each GFRN pathway. b Western blot analysis for MCL-1, BIM, and B-actin control across 20 breast cancer cell lines of either the survival phenotype or growth phenotype. c, d Boxplots between samples classified as the survival phenotype or growth phenotype for c MCL-1 gene expression (log2 (Transcript per million)) in TCGA data, d BIM gene expression (log2 (Transcript per million)) in TCGA and ICBP data, and protein expression (RPPA score) in TCGA data. Student t-tests were performed to determine significance

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