Fig. 2
From: Migration of mitochondrial DNA in the nuclear genome of colorectal adenocarcinoma
Distribution of NUMT proportions in tumor and normal genomes. a Distribution of NUMT proportions in 57 samples with matched tumor and blood-derived normal genomes. NUMT proportion is defined as the ratio between NUMT read count and total mapped read count on a genome-wide scale. The mean and standard deviation, respectively, across the 57 samples are 8.31 × 10−6 and 7.11 × 10−6 for tumor genomes and 2.65 × 10−6 and 2.49 × 10−6 for normal genomes. A two-tailed paired t-test conducted between the NUMT proportions for 57 (COAD + READ) samples revealed a P value of 1.63 × 10−5. When comparing the NUMT proportions between the cancer site group versus blood-derived group using a two-tailed unequal variance t-test, a P value of 1.43 × 10−5 was observed for COAD samples (N = 36) and 3.82 × 10−3 for READ samples (N = 21). b Fold change in the tumor NUMT proportions compared to blood-derived normal genomes across colon (COAD) and rectum (READ) cancer samples. Tumor genomes contained 4.42-fold more NUMTs than blood-derived normal genomes. A two-tailed unequal variance t-test conducted between the NUMT abundance of colon cancer samples (N = 36) and rectal cancer samples (N = 21) revealed a P value of 0.91, indicating no difference in the NUMT abundance between the two cancer sites, colon and rectum. c Right-skewed distribution, log transformed, and one-tailed paired t-test performed on tumor and matched blood-derived normal samples to determine the statistical significance (P value 8.79 × 10−13) of the log-transformed NUMT abundance levels