Fig. 10
From: Migration of mitochondrial DNA in the nuclear genome of colorectal adenocarcinoma
Mechanism underlying numtogenesis. Our observations support the role of Yme1 in numtogenesis. The role of Yme1 in the regulation of mitophagy is well established. Mitophagy is a stringent mechanism that controls the quality of mitochondria in cells by degrading dysfunctional mitochondria. Compromised mitophagy due to altered Yme1 function leads to accumulation of undigested mtDNA in the cytoplasm that ultimately ends up in the nucleus, a process we have named numtogenesis