From: Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits
 | Original study | Association with AMD | Frequency in |  | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Variant | Chromo some | Position [hg19] | Phenotype | Locus name | Locus boundary in 1Â MÂ bp [hg19] | Effect allelea | Effect sizea | Odds ratio | 95% CIb | p value raw | p value adjc | Q-value raw | Q-value adjc | Controls | Cases | Imputation quality |
rs7523273 | 1 | 207977083 | SCZ | CD46/CR1L | 207.8–208.1 | A | 1.063 (OR) | 1.078 | 1.042-1.116 | 1.37E-05 | 2.51E-05 | 0.0009 | 5.91E-05 | 0.667 | 0.681 | 0.972 |
rs1550094 | 2 | 233385396 | MYP | PRSS56 | 233.3–233.5 | G | 1.087 (HR) | 1.067 | 1.030-1.106 | 0.0003 | 0.0019 | 0.0093 | 0.0021 | 0.290 | 0.304 | 0.867 |
rs9844666 | 3 | 135974216 | HGT | STAG1 | 135.5–136.9 | G | 1.024 (SL) | 1.079 | 1.039-1.120 | 6.70E-05 | 0.0002 | 0.0029 | 0.0003 | 0.753 | 0.768 | 0.999 |
rs7432375 | 3 | 136288405 | SCZ | STAG1 | 135.5–136.9 | G | 1.073 (OR) | 0.942 | 0.911-0.973 | 0.0003 | 0.0004 | 0.0095 | 0.0005 | 0.605 | 0.593 | 0.999 |
rs13091182 | 3 | 141133960 | MYP | ZBTB38 | 141–141.3 | G | 1.064 (OR) | 0.929 | 0.898-0.960 | 1.65E-05 | 5.65E-06 | 0.0010 | 2.26E-05 | 0.668 | 0.651 | 0.996 |
rs3774959 | 4 | 103511114 | UC | NFKB1 | 103.3–103.6 | A | 1.119 (OR) | 0.928 | 0.898-0.959 | 1.11E-05 | 4.44E-07 | 0.0007 | 7.71E-06 | 0.357 | 0.341 | 0.964 |
rs2277027 | 5 | 156932376 | LGF | ADAM19 | 156.8–157.1 | A | 1.462 (SL) | 1.096 | 1.059-1.133 | 1.31E-07 | 2.75E-06 | 1.50E-05 | 1.28E-05 | 0.651 | 0.667 | 1.000 |
rs2814982 | 6 | 34546560 | TC | C6ORF106 | 34.4–34.9 | C | 1.045 (SL) | 1.118 | 1.061-1.178 | 2.67E-05 | 4.82E-05 | 0.0014 | 0.0001 | 0.889 | 0.898 | 0.980 |
rs2207139 | 6 | 50845490 | BMI | TFAP2B | 50.7–51 | G | 1.046 (SL) | 0.921 | 0.883-0.961 | 0.0001 | 0.0004 | 0.0058 | 0.0006 | 0.179 | 0.165 | 0.997 |
rs11776767 | 8 | 10683929 | TG | PINX1 | 10.5–10.8 | C | 1.022 (OR) | 0.936 | 0.905-0.967 | 8.83E-05 | 0.0089 | 0.0037 | 0.0089 | 0.380 | 0.370 | 0.999 |
rs3217992 | 9 | 22003223 | CAD | CDKN2B | 21.9–22.2 | T | 1.160 (OR) | 0.914 | 0.884-0.945 | 1.07E-07 | 1.18E-05 | 1.35E-05 | 3.67E-05 | 0.394 | 0.375 | 1.000 |
rs7865618 | 9 | 22031005 | ODCA; VCDR | CDKN2B | 21.9–22.2 | A | 1.023 (SL) | 0.937 | 0.907-0.968 | 9.23E-05 | 6.12E-05 | 0.0037 | 0.0001 | 0.593 | 0.579 | 1.000 |
rs7866783 | 9 | 22056359 | POAG | CDKN2B | 21.9–22.2 | G | 1.451 (OR) | 0.936 | 0.906-0.967 | 6.67E-05 | 2.53E-05 | 0.0029 | 5.91E-05 | 0.594 | 0.579 | 0.995 |
rs11191548 | 10 | 104846178 | BP | NT5C2 | 104.4–105.2 | T | 2.989 (SL) | 0.902 | 0.853-0.954 | 0.0003 | 0.0012 | 0.0092 | 0.0014 | 0.914 | 0.906 | 1.000 |
rs11191560 | 10 | 104869038 | BMI | NT5C2 | 104.4–105.2 | C | 1.031 (SL) | 1.110 | 1.049-1.173 | 0.0003 | 0.0012 | 0.0087 | 0.0014 | 0.086 | 0.094 | 0.996 |
rs634552 | 11 | 75282052 | HGT | SERPINH1 | 75.2–75.4 | T | 1.040 (SL) | 1.120 | 1.069-1.173 | 2.08E-06 | 1.47E-05 | 0.0002 | 4.11E-05 | 0.130 | 0.144 | 0.999 |
rs11830103 | 12 | 123823546 | HGT | SBNO1 | 123.3–124 | G | 1.036 (SL) | 1.082 | 1.040-1.125 | 9.13E-05 | 0.0028 | 0.0037 | 0.0029 | 0.205 | 0.216 | 1.000 |
rs4901977 | 14 | 60789176 | VCDR | SIX6 | 60.7–61.3 | T | 1.011 (SL) | 0.927 | 0.895-0.959 | 1.56E-05 | 8.40E-06 | 0.0010 | 2.94E-05 | 0.319 | 0.306 | 0.996 |
rs2093210 | 14 | 60957279 | HGT | SIX6 | 60.7–61.3 | C | 1.033 (SL) | 0.920 | 0.890-0.950 | 5.00E-07 | 1.37E-06 | 4.34E-05 | 7.71E-06 | 0.417 | 0.401 | 0.997 |
rs33912345 | 14 | 60976537 | POAG | SIX6 | 60.7–61.3 | C | 1.320 (OR) | 0.919 | 0.889-0.949 | 3.51E-07 | 1.19E-06 | 3.21E-05 | 7.71E-06 | 0.413 | 0.397 | 1.000 |
rs10483727 | 14 | 61072875 | ODCA | SIX6 | 60.7–61.3 | T | 1.026 (SL) | 0.915 | 0.886-0.946 | 1.11E-07 | 1.06E-06 | 1.35E-05 | 7.71E-06 | 0.414 | 0.396 | 0.999 |
rs1555399 | 14 | 67984370 | PD | PLEKHH1 | 67.9–68.1 | T | 1.115 (OR) | 0.929 | 0.899-0.959 | 6.27E-06 | 0.0002 | 0.0004 | 0.0003 | 0.517 | 0.502 | 0.997 |
rs11627032 | 14 | 93104072 | BRC | RIN3 | 93–93.2 | T | 1.060 (OR) | 1.070 | 1.032-1.109 | 0.0002 | 0.0014 | 0.0086 | 0.0015 | 0.728 | 0.739 | 0.931 |
rs1378942 | 15 | 75077367 | BP | CSK | 74.9–75.3 | C | 1.846 (SL) | 0.918 | 0.887-0.950 | 8.52E-07 | 1.38E-06 | 7.06E-05 | 7.71E-06 | 0.345 | 0.328 | 1.000 |
rs2290400 | 17 | 38066240 | T1D | GSDMB | 37.8–38.2 | C | 1.080 (OR) | 1.068 | 1.034-1.103 | 5.47E-05 | 7.29E-05 | 0.0026 | 0.0001 | 0.494 | 0.508 | 1.000 |
rs9303280 | 17 | 38074031 | ALG | GSDMB | 37.8–38.2 | C | 1.070 (SL) | 0.941 | 0.911-0.971 | 0.0002 | 0.0001 | 0.0068 | 0.0002 | 0.510 | 0.497 | 0.984 |
rs386000 | 19 | 54792761 | HDL | LILRA3 | 54.7–54.9 | C | 1.049 (SL) | 1.096 | 1.053-1.141 | 6.24E-06 | 0.0006 | 0.0004 | 0.0008 | 0.199 | 0.211 | 0.782 |
rs1547014 | 22 | 29100711 | VCDR | CHEK | 28.5–29.2 | C | 1.013 (SL) | 0.936 | 0.904-0.969 | 0.0002 | 6.78E-05 | 0.0068 | 0.0001 | 0.708 | 0.695 | 0.999 |