Fig. 8
From: Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis
Genes altered by IMQ overlap significantly with those altered in other human skin conditions besides psoriasis (eschars, acne, infection, wounding). a Match scores. Scores represent the average fold change (FC) of the 200 genes most strongly increased in each disease (IMQ/CTL) and the 200 genes most strongly decreased in each disease (CTL/IMQ). Diseases are ranked by average score across IMQ phenotypes. b Genes increased in Mediterranean spotted fever (MSF) eschars and IMQ phenotypes. c GO BP terms enriched among genes increased in MSF eschars and IMQ phenotypes. d The highest score is shown for each sex–strain combination. e 129/SvJ females. Overlap of genes increased in IMQ dermatitis, burn wounds, and psoriasis lesions (FDR <0.10 in each case). f MOLF males. Overlap of genes increased in IMQ dermatitis, L. braziliensis-infected cutaneous lesions, and psoriasis lesions (FDR <0.10 in each case). F female, FC fold change, M male