Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants

Table 4 Uric acid top hits

Gene	SNP	Chr	Position	Effect allele	GS minor allele frequency	HRC MAF	GS p value	GS effect size	Meta top SNP	Meta p value
*SLC2A9*	rs6449213	4	9994215	T	0.165	0.1857	1.93E-17	0.592	rs12498742	<1 E − 700
FAM134B	rs75869162	5	16617922	A	0.005	0.0019	1.57E-08	2.24	rs386845	1.18E-02
RP11-430H10.4	rs141208451	11	45538920	A	0.005	0.0011	3.13E-09	2.32	rs11038475	7.36E-03
ZNF160	rs187171029	19	53599256	T	0.006	0.0040	1.84E-08	2	rs16984293	2.58E-02

Summary of top hits of the imputed GWAS analysis of uric acid in 2077 Generation Scotland participants, compared with top hits in a meta-analysis reported in the GUGC. Top hits were extracted from the region within 100,000 bases of the imputed GWAS top SNP. Entries in bold are within 500,000 bases of a SNP that reached genome-wide significance in the genotyped GWAS analysis

ISSN: 1756-994X