Baseline characteristic | N | dbSNP ID | Minor allele frequency | p value | Gene | Imputation quality | Gene association reported previously? | Region significant in genotyped data? |
---|---|---|---|---|---|---|---|---|
Cardiometabolic | ||||||||
 Diastolic blood pressure | 19,546 | rs142892876 | 0.0010 | 4.97E-08 | CNTN6 | 0.75 | No | No |
 | rs528908640 | 0.0005 | 1.93E-08 | OPA1 | 0.80 | No | No | |
 | rs568998724 | 0.0007 | 2.91E-08 | - | 0.78 | No | No | |
 | rs187680191 | 0.0006 | 2.94E-09 | NRG4 | 0.51 | No | No | |
 Systolic blood pressure | 19,547 | None |  |  | None |  |  |  |
 Pulse pressure | 19,546 | None |  |  | None |  |  |  |
 Heart rate | 19,920 | rs9970334 | 0.4474 | 4.38E-08 | ICMT | 0.90 | Yes | No |
 | rs755291044 | 0.0017 | 1.80E-08 | - | 0.90 | No | No | |
 | rs145669495 | 0.0022 | 2.01E-08 | CSMD1 | 0.90 | No | No | |
 | rs142916219 | 0.0037 | 2.21E-08 | ASPH | 0.85 | No | No | |
 | rs365990 | 0.3637 | 4.04E-10 | MYH6 | 0.99 | Yes | GWS | |
 | rs148397504 | 0.0008 | 3.21E-09 | - | 0.45 | No | No | |
Biochemistry | ||||||||
 Serum creatinine | 16,347 | rs548873184 | 0.0010 | 1.47E-08 | LINC00626 | 0.96 | No | No |
 | rs573421908 | 0.0027 | 1.35E-08 | SLC35F3 | 0.80 | Yes | No | |
 | rs62412107 | 0.0660 | 1.87E-08 | - | 0.79 | No | No | |
 | rs3812036 | 0.2301 | 1.13E-10 | SLC34A1 | 0.96 | Yes | GWS | |
 Fasting plasma glucose (with diabetics) | 16,174 | rs560887 | 0.2907 | 6.02E-68 | G6PC2 | 1.00 | Yes | GWS |
 | rs9873618 | 0.2871 | 9.83E-12 | SLC2A2 | 0.99 | Yes | GWS | |
 | rs917793 | 0.1831 | 2.51E-24 | YKT6 | 0.98 | Yes | GWS | |
 | rs13266634 | 0.3153 | 3.66E-11 | SLC30A8 | 1.00 | Yes | GWS | |
 | rs533883198 | 0.0027 | 3.86E-08 | - | 0.84 | No | No | |
 | rs7981781 | 0.2337 | 1.40E-08 | PDX1 | 0.98 | Yes | GWS | |
 | rs370189685 | 0.0014 | 7.32E-09 | WDR4 | 0.63 | No | No | |
 Fasting plasma glucose (diabetics removed) | 15,226 | rs79687284 | 0.0364 | 1.87E-08 | - | 0.78 | Yes | GWS |
 | rs780095 | 0.4267 | 8.20E-09 | GCKR | 1.00 | Yes | GWS | |
 | rs560887 | 0.2907 | 2.09E-75 | G6PC2 | 1.00 | Yes | GWS | |
 | rs8192675 | 0.2839 | 8.41E-11 | SLC2A2 | 1.00 | Yes | GWS | |
 | rs917793 | 0.1831 | 1.46E-28 | YKT6 | 0.98 | Yes | GWS | |
 | rs11558471 | 0.3227 | 4.63E-13 | SLC30A8 | 1.00 | Yes | GWS | |
 | rs143399767 | 0.0108 | 1.42E-08 | Y_RNA | 0.89 | No | No | |
 | rs7981781 | 0.2337 | 5.01E-10 | PDX1 | 0.98 | Yes | GWS | |
 | rs370189685 | 0.0014 | 2.75E-08 | WDR4 | 0.63 | No | Suggestive | |
 HDL cholesterol | 19,223 | rs149963466 | 0.0016 | 3.18E-08 | - | 0.76 | No | No |
 | rs76183280 | 0.0048 | 4.14E-08 | AC016735.2 | 0.78 | No | No | |
 | rs4841132 | 0.0925 | 1.08E-08 | RP11-115 J16.1 | 1.00 | Yes | Suggestive | |
 | rs15285 | 0.2675 | 1.16E-18 | LPL | 1.00 | Yes | GWS | |
 | rs2740488 | 0.2745 | 2.53E-08 | ABCA1 | 1.00 | Yes | GWS | |
 | rs138326449 | 0.0032 | 2.92E-20 | APOC3 | 0.85 | Yes | No | |
 | rs114529226 | 0.0038 | 6.98E-09 | IGHVII-33-1 | 0.64 | No | No | |
 | rs261290 | 0.3442 | 2.78E-25 | ALDH1A2 | 1.00 | Yes | GWS | |
 | rs3764261 | 0.3261 | 1.40E-113 | CETP | 1.00 | Yes | GWS | |
 | rs143264468 | 0.0010 | 1.99E-09 | LRRC29 | 0.81 | Yes | Suggestive | |
 | rs72836561 | 0.0294 | 1.55E-11 | CD300LG | 0.87 | Yes | No | |
 | rs149615216 | 0.0119 | 3.20E-09 | LIPG | 0.97 | Yes | Suggestive | |
 | rs116843064 | 0.0230 | 5.57E-10 | ANGPTL4 | 0.84 | Yes | No | |
 | rs7412 | 0.0779 | 5.95E-14 | APOE | 0.98 | Yes | GWS | |
 | rs453755 | 0.2480 | 3.22E-08 | LILRA3 | 0.92 | Yes | No | |
 | rs435306 | 0.2547 | 2.87E-08 | PLTP | 1.00 | Yes | Suggestive | |
 Cholesterol | 19,259 | rs11591147 | 0.0169 | 1.83E-17 | PCSK9 | 0.98 | Yes | GWS |
 | rs10889333 | 0.3601 | 2.12E-10 | DOCK7 | 1.00 | Yes | GWS | |
 | rs12740374 | 0.2288 | 8.19E-22 | CELSR2 | 1.00 | Yes | GWS | |
 | rs672889 | 0.1356 | 3.77E-16 | - | 1.00 | Yes | GWS | |
 | rs75331444 | 0.0720 | 1.87E-11 | ABCG8 | 0.99 | Yes | GWS | |
 | rs12916 | 0.3970 | 6.35E-11 | HMGCR | 0.99 | Yes | GWS | |
 | rs74617384 | 0.0838 | 3.02E-09 | LPA | 0.93 | Yes | No | |
 | rs4841133 | 0.0929 | 2.51E-09 | RP11-115 J16.1 | 1.00 | Yes | Suggestive | |
 | rs2000999 | 0.1776 | 7.01E-09 | HPR | 0.99 | Yes | Suggestive | |
 | rs10412048 | 0.1086 | 5.00E-25 | - | 0.98 | Yes | GWS | |
 | rs7412 | 0.0779 | 5.22E-94 | APOE | 0.98 | Yes | GWS | |
 Urea | 19,293 | rs760077 | 0.4247 | 6.24E-09 | MTX1 | 0.98 | Yes | Suggestive |
 | rs16862780 | 0.1574 | 3.03E-10 | RP11-132 N15.3 | 1.00 | Yes | GWS | |
 | rs112647987 | 0.0680 | 3.07E-08 | - | 0.99 | No | No | |
 | rs6950388 | 0.1872 | 1.57E-08 | UNCX | 0.95 | Yes | GWS | |
 | rs10224210 | 0.2799 | 5.71E-09 | PRKAG2 | 0.92 | Yes | Suggestive | |
Anthropometric | ||||||||
 Body mass index | 19900 | rs73139123 | 0.1830 | 1.34E-09 | - | 0.96 | Yes | GWS |
 | rs10498218 | 0.0012 | 3.98E-08 | COL4A4 | 0.84 | Yes | No | |
 | rs149913955 | 0.0059 | 2.18E-08 | RP11-624 L4.1 | 0.74 | No | No | |
 | rs571835655 | 0.0011 | 6.61E-09 | - | 0.82 | No | No | |
 | rs55872725 | 0.3951 | 5.71E-21 | FTO | 1.00 | Yes | GWS | |
 Height | 19,965 | rs146949893 | 0.0031 | 4.49E-08 | RP1-35C21.2 | 0.72 | No | No |
 | rs558671668 | 0.0062 | 2.53E-08 | RP11-317P15.6 | 0.80 | No | No | |
 | rs6765866 | 0.0007 | 2.05E-08 | CMTM8 | 0.59 | No | No | |
 | rs1991431 | 0.4338 | 5.25E-13 | ZBTB38 | 1.00 | Yes | GWS | |
 | rs35362908 | 0.1006 | 7.04E-09 | LCORL | 0.73 | Yes | No | |
 | rs552283803 | 0.0016 | 3.99E-08 | ARHGAP24 | 0.79 | No | No | |
 | rs755546258 | 0.0007 | 2.58E-08 | DAP | 0.72 | No | No | |
 | rs72742734 | 0.0537 | 3.61E-08 | NPR3 | 1.00 | Yes | Suggestive | |
 | rs554379257 | 0.0006 | 4.83E-08 | CTD-2023 N9.1 | 0.44 | No | No | |
 | rs7766641 | 0.2551 | 3.32E-13 | HIST1H2BE | 1.00 | Yes | GWS | |
 | rs57026767 | 0.1550 | 4.50E-11 | C6orf1 | 1.00 | Yes | GWS | |
 | rs566773279 | 0.0005 | 1.17E-08 | - | 0.69 | No | No | |
 | rs1490384 | 0.4851 | 7.09E-10 | - | 1.00 | Yes | GWS | |
 | rs7753012 | 0.3072 | 7.60E-14 | GPR126 | 0.99 | Yes | GWS | |
 | rs184469050 | 0.0088 | 1.58E-08 | - | 0.89 | No | No | |
 | rs144225905 | 0.0010 | 2.13E-09 | - | 0.46 | No | No | |
 | rs7952436 | 0.0896 | 1.91E-12 | KDM2A | 0.88 | Yes | No | |
 | rs634552 | 0.1365 | 2.30E-08 | SERPINH1 | 0.98 | Yes | GWS | |
 | rs76895963 | 0.0285 | 3.43E-08 | CCND2 | 0.78 | No | ||
 | rs770307181 | 0.0005 | 1.09E-08 | - | 0.50 | No | No | |
 | rs139770682 | 0.0005 | 4.55E-08 | - | 0.72 | No | No | |
 | rs11614062 | 0.1943 | 2.09E-08 | SOCS2-AS1 | 0.99 | Yes | GWS | |
 | rs75061684 | 0.0006 | 5.33E-10 | - | 0.49 | No | No | |
 | rs16942323 | 0.0344 | 1.09E-11 | ACAN | 0.93 | Yes | No | |
 | rs8096254 | 0.2598 | 4.32E-12 | CABLES1 | 1.00 | Yes | GWS | |
 | rs6060402 | 0.3585 | 2.80E-13 | - | 0.98 | Yes | GWS | |
 Waist-to-hip ratio | 19,695 | rs72959041 | 0.0566 | 2.54E-14 | RSPO3 | 0.90 | Yes | Suggestive |
 | rs149924309 | 0.0023 | 3.70E-08 | - | 0.81 | No | No | |
 | rs187209742 | 0.0023 | 4.91E-08 | SERPINA10 | 0.70 | No | No | |
 | rs751156121 | 0.0006 | 1.29E-08 | - | 0.78 | No | No | |
 Body fat | 19,480 | rs10921288 | 0.0235 | 1.04E-08 | - | 0.99 | No | GWS |
 | rs142101835 | 0.0022 | 3.25E-08 | IRS1 | 0.69 | Yes | No | |
 | rs560546550 | 0.0007 | 3.17E-09 | WDR41 | 0.89 | No | No | |
 | rs571835655 | 0.0011 | 2.03E-08 | - | 0.82 | No | No | |
 | rs55872725 | 0.3951 | 5.55E-16 | FTO | 1.00 | Yes | GWS | |
 | rs141793746 | 0.0030 | 3.31E-08 | DYM | 0.86 | No | No | |
NHS EHR linkage | ||||||||
 Serum urate | 2077 | rs6449213 | 0.1652 | 1.93E-17 | SLC2A9 | 1.00 | Yes | GWS |
 | rs75869162 | 0.0054 | 1.57E-08 | FAM134B | 0.80 | No | No | |
 | rs141208451 | 0.0053 | 3.13E-09 | RP11-430H10.4 | 0.86 | No | No | |
 | rs187171029 | 0.0060 | 1.84E-08 | ZNF160 | 0.91 | No | No |