Skip to main content

Table 1 Breakdown of samples used for the identification of IVF-DMRs and potential covariates

From: DNA methylation changes at infertility genes in newborn twins conceived by in vitro fertilisation

Group

Total number of twins (number of complete sets)

Zygosity and chorionicitya

Sexb

Birth weight (kg): mean(sd)

Maternal age (years): mean (sd)

Maternal smoking (percentage smokers)

Ovarian stimulation

ICSI

GIFT

Frozen embryo

WBCs

IVF

40 (20)

10 MZ MC

30 DZ DC

18 (F)

22 (M)

2.57 (4.77)

36 (4)

20%

6 (No)

34 (Yes)

22 (No)

18 (Yes)

-

28 (No)

12 (Yes)

Non-IVF

58 (29)

14 MZ MC

12 MZ DC

32 DZ DC

34 (F)

24 (M)

2.58 (3.99)

32 (5)

28%

56 (No)

2 (Yes)

-

56 (No)

2 (Yes)

-

CBMCs

IVF

35 (16)

9 MZ MC

1 MZ DC

25 DZ DC

16 (F)

19 (M)

2.50 (4.42)

35 (5)

23%

1 (No)

34 (Yes)

14 (No)

21 (Yes)

-

24 (No)

11 (Yes)

Non-IVF

47 (22)

12 MZ MC

10 MZ DC

25 DZ DC

30 (F)

17 (M)

2.60 (3.48)

32 (4)

28%

45 (No)

2 (Yes)

-

45 (No)

2 (Yes)

-

  1. a MZ monozygotic, DZ dizygotic, MC monochorionic, DC dichorionic
  2. b F female, M male
  3. GIFT gamete intra-fallopian transfer, ICSI intracytoplasmic sperm injection, sd standard deviation