Characterization of oral and gut microbiome temporal variability in hospitalized cancer patients

Table 1 Clinical features of 59 AML patients

Characteristic	Number (%)
Demographics
Median age in years ^a	55 (49–68)
Male	31 (52.5)
Female	28 (47.5)
Median days on study	28 (25–35)
Median number of oral samples	8 (6–9)
Median number of stool samples	6 (4–8)
Chemotherapy
Hypomethylators^b	14 (23.7)
Non-fludarabine high intensity^c	19 (32.2)
Fludarabine-containing^d	19 (32.2)
Other^e	7 (11.8)
Chemotherapeutic response
Complete remission after IC	20 (33.8)
Overall response rate^f	43 (72.8)
Infections^g
Microbiologically documented infection	15 (25.4)
Clinically documented infection	14 (23.7)
No infection	30 (50.8)
Antimicrobial administration
Received treatment antibiotics^h	53 (89.8)
Carbapenem >72 h	39 (66.1)
Piperacillin/tazobactam >72 h	14 (23.7)
Cefepime >72 h	26 (44.1)
Received prophylactic antibiotics	59 (100)
Median number of antibiotics administered	6 (4–7)
Median number of days exposed to all antibioticsⁱ	28 (24–35)
Median number of days exposed to treatment antibiotics	16 (9–24)
Median number of days exposed to prophylactic antibiotics	16 (8–28)

^a All median values in this table have the interquartile range in parentheses
^b These chemotherapies included: 1) vasoroxin in combination with decitabine; 2) decitabine alone; 3) azacytidine in combination with pracinostat; 4) azacytidine in combination with quidartinib; and 5) SGI-110
^c These chemotherapies included: 1) CIA, 2) CLIA, 3) or CIA + sorafanib
^d These chemotherapies included: 1) FLAG-Ida or 2) FIA regimens
^eOther chemotherapies included:1) omacetaxine in combination with low-dose cytarabine or 2) Clad + LDAC
^f Includes CR (morphologic complete remission), CRi (morphologic complete remission with incomplete bloodcount recovery), and CRp (morphologic complete remission with incomplete platelet recovery)
^g Specific information on microbiologically and clinically documented infections can be found in the “Methods”
^h Refers to any antibiotic/antimicrobial-based therapy given for suspected or proven infection, that is, not included as prophylaxis (cephalosporins or fluoroquinilones). Denoted are the three most common broad spectrum antibiotics given in the study. Note that numbers of individual antibiotics add up to >100% because some patients received more than one of the listed antimicrobials during IC
ⁱ Includes prophylactic antibiotics

ISSN: 1756-994X