Fig. 1
From: 3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets
Mutational 3D cluster analysis method and related resources. a Process of going beyond single-residue hotspots by considering occurrence in 3D clusters. The colors of different types of mutated residues in 3D clusters are defined in the bottom panel and used throughout the manuscript. b Mutations in 3D clusters can be explored via the web resource http://3dhotspots.org. The results are also made available via a web API service for use by other bioinformatics tools, and mutations viewed in the cBioPortal for Cancer Genomics are annotated if they are part of an identified 3D cluster. The identified 3D clusters are likely to change as the cancer genomics and 3D structure databases grow