Fig. 5From: iCAGES: integrated CAncer GEnome Score for comprehensively prioritizing driver genes in personal cancer genomesPerformance of the third layer of iCAGES. a–c Kaplan–Meier survival curve for 124 TCGA patients with targeted therapy with unknown response whose data were also used in the Rubio-Perez et al. study (testing dataset I). a Red and blue curves represent patients whose treatments do and do not contain iCAGES-predicted first tier drugs, respectively. Red and blue areas represent the 95% confidence interval for the survival curve. b Red and blue curves represent patients whose treatments do and do not contain Rubio-Perez et al.-predicted drugs, respectively. c Red and blue curves represent patients whose treatments do and do not contain DGIdb-predicted drugs. d Number of TCGA patients with targeted therapy with complete response or progressive disease who received correct iCAGES-predicted drugs (blue), DGIdb drugs (gray), Rubio-Perez et al. tier one drugs (orange). e Number of patients used in Rubio-Perez et al. study who can potentially benefit from iCAGES (without pathway component from BioSystem) predicted drugs from three tiers (blue), iCAGES-predicted drugs (green), Rubio-Perez et al.-predicted drugs (orange). Significant advantage of iCAGES compared to other tools is indicated as ***P ≤ 0.0001 and Bonferroni correction (testing dataset III)Back to article page