Fig. 3

Informativeness of using cross-disease GWAS summary data in characterising relationships between immunological disorders. a Gene scoring from GWAS SNPs prior to network analysis. b Heatmap of cross-disease gene scores for 11 common immunological disorders based on ImmunoBase GWAS summary data. c Consensus neighbour-joining tree based on the gene-scoring matrix resolves disease classification/taxonomy according to the genetic and cellular basis of autoinflammation and autoimmunity. Subdivided into 1) polygenic autoinflammatory diseases with a prominent autoinflammatory component, 2) polygenic autoimmune diseases with a prominent autoimmune component, and 3) mixed diseases having both components. Inter-disease distance is defined as the cumulative difference in gene scores