Fig. 1
From: Non-coding single nucleotide variants affecting estrogen receptor binding and activity
Analysis pipeline for detecting regulatory SNVs from ChIP-seq data. The above pipeline was utilized to extract and rank regSNVs based on their impact on the corresponding TF binding. MACS and GATK tools were recruited to identify binding sites and SNVs, respectively. The SNVs and binding peaks were overlapped and then regSNVs were ranked depending on how they alter EREs. One of the top candidates was selected for further functional studies