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Table 5 Multiple linear regression analysis of talinolol (50 mg) clearance

From: Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transporters

Factor

r (r2)a

Coefficient

p

All factors

0.55 (0.30)

-

<0.001

Sex

0.20 (0.04)

0.184

0.044

Age

0.02 (<0.01)

0.001

NS

Body mass index

0.20 (0.04)

0.022

0.041

Protein consumption

−0.20 (0.04)

−0.144

0.046

Vegetable consumption

−0.20 (0.04)

−0.114

0.050

MDR1 C1236T

−0.05 (<0.01)

−0.039

NS

MDR1 G2677T/A

−0.03 (<0.01)

−0.020

NS

  1. NS not significant. aThe correlation is given for the total model with all factors. The r2 (coefficient of determination) may indicate the fraction of the total variation explained by the respective factors