Fig. 1From: A case study of an integrative genomic and experimental therapeutic approach for rare tumors: identification of vulnerabilities in a pediatric poorly differentiated carcinomaClinical presentation of metastatic PDC. a Representative scalp nodule. b, c Diagnostic imaging demonstrating the presence of multiple lytic lesions of the calvarium (b) as well as heterogeneous lesions within the liver with associated hepatosplenomegaly (c). d–i Immunohistochemical staining consistent with diagnosis of a PDC with high proliferative index: (d) H&E (200X), (e) cytokeratin 5 (200X), (f) cytokeratin 10 (100X), (g) EpCAM (400X), (h) ß-catenin (400X), (i) Ki67 (200X). Scale bar = 100 μmBack to article page