Fig. 1
From: Application of RNAi-induced gene expression profiles for prognostic prediction in breast cancer
Overview of computational analysis in this study. Briefly, we utilize knockdown experiments of BRCA1 or RAD51 in combination with breast cancer patient gene expression data to estimate the similarity score between the knockdown profiles and tumor expression profiles. The score can be used to predict sporadic cancers from hereditary cancers, predict patient survival outcome, predict chemosensitivity, and correlate with genome instability