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Table 7 Gene Ontology classification of protein-coding genes by pathway

From: Epigenomic and metabolic responses of hypothalamic POMC neurons to gestational nicotine exposure in adult offspring

Category name (PANTHER pathway accession number)

Number of gene hits

Percent of gene hit against total number of genes

Percent of gene hit against total number of pathway hits

2-arachidonoylglycerol biosynthesis (P05726)

4

0.00 %

0.10 %

5-Hydroxytryptamine biosynthesis (P04371)

2

0.00 %

0.00 %

5-Hydroxytryptamine degradation (P04372)

3

0.00 %

0.10 %

5HT1 type receptor mediated signaling pathway (P04373)

25

0.20 %

0.60 %

5HT2 type receptor mediated signaling pathway (P04374)

39

0.30 %

1.00 %

5HT3 type receptor mediated signaling pathway (P04375)

12

0.10 %

0.30 %

5HT4 type receptor mediated signaling pathway (P04376)

16

0.10 %

0.40 %

Acetate utilization (P02722)

3

0.00 %

0.10 %

Activin-beta signaling pathway (P06210)

3

0.00 %

0.10 %

Adenine and hypoxanthine salvage pathway (P02723)

6

0.10 %

0.10 %

Adrenaline and noradrenaline biosynthesis (P00001)

22

0.20 %

0.50 %

Alanine biosynthesis (P02724)

2

0.00 %

0.00 %

ALP23B_signaling_pathway (P06209)

3

0.00 %

0.10 %

Alpha adrenergic receptor signaling pathway (P00002)

20

0.20 %

0.50 %

Alzheimer disease-amyloid secretase pathway (P00003)

50

0.40 %

1.20 %

Alzheimer disease-presenilin pathway (P00004)

74

0.60 %

1.80 %

Aminobutyrate degradation (P02726)

2

0.00 %

0.00 %

Androgen/estrogene/progesterone biosynthesis (P02727)

3

0.00 %

0.10 %

Angiogenesis (P00005)

125

1.10 %

3.10 %

Angiotensin II-stimulated signaling through G proteins and beta-arrestin (P05911)

30

0.30 %

0.70 %

Apoptosis signaling pathway (P00006)

80

0.70 %

2.00 %

Arginine biosynthesis (P02728)

4

0.00 %

0.10 %

Ascorbate degradation (P02729)

2

0.00 %

0.00 %

Asparagine and aspartate biosynthesis (P02730)

4

0.00 %

0.10 %

ATP synthesis (P02721)

6

0.10 %

0.10 %

Axon guidance mediated by netrin (P00009)

29

0.30 %

0.70 %

Axon guidance mediated by semaphorins (P00007)

18

0.20 %

0.40 %

Axon guidance mediated by Slit/Robo (P00008)

18

0.20 %

0.40 %

B cell activation (P00010)

49

0.40 %

1.20 %

Beta1 adrenergic receptor signaling pathway (P04377)

26

0.20 %

0.60 %

Beta2 adrenergic receptor signaling pathway (P04378)

26

0.20 %

0.60 %

Beta3 adrenergic receptor signaling pathway (P04379)

11

0.10 %

0.30 %

Blood coagulation (P00011)

22

0.20 %

0.50 %

BMP_signaling_pathway-drosophila (P06211)

2

0.00 %

0.00 %

Cadherin signaling pathway (P00012)

103

0.90 %

2.50 %

Carnitine and CoA metabolism (P02732)

1

0.00 %

0.00 %

Carnitine metabolism (P02733)

1

0.00 %

0.00 %

Cell cycle (P00013)

17

0.10 %

0.40 %

Cholesterol biosynthesis (P00014)

9

0.10 %

0.20 %

Circadian clock system (P00015)

9

0.10 %

0.20 %

Coenzyme A biosynthesis (P02736)

6

0.10 %

0.10 %

Cortocotropin releasing factor receptor signaling pathway (P04380)

27

0.20 %

0.70 %

Cysteine biosynthesis (P02737)

1

0.00 %

0.00 %

Cytoskeletal regulation by Rho GTPase (P00016)

57

0.50 %

1.40 %

De novo purine biosynthesis (P02738)

19

0.20 %

0.50 %

De novo pyrimidine deoxyribonucleotide biosynthesis (P02739)

6

0.10 %

0.10 %

De novo pyrmidine ribonucleotides biosythesis (P02740)

8

0.10 %

0.20 %

DNA replication (P00017)

19

0.20 %

0.50 %

Dopamine receptor mediated signaling pathway (P05912)

48

0.40 %

1.20 %

DPP_signaling_pathway (P06213)

2

0.00 %

0.00 %

DPP-SCW_signaling_pathway (P06212)

2

0.00 %

0.00 %

EGF receptor signaling pathway (P00018)

101

0.90 %

2.50 %

Endogenous_cannabinoid_signaling (P05730)

18

0.20 %

0.40 %

Endothelin signaling pathway (P00019)

65

0.60 %

1.60 %

Enkephalin release (P05913)

17

0.10 %

0.40 %

FAS signaling pathway (P00020)

24

0.20 %

0.60 %

FGF signaling pathway (P00021)

86

0.70 %

2.10 %

Flavin biosynthesis (P02741)

2

0.00 %

0.00 %

Folate biosynthesis (P02742)

2

0.00 %

0.00 %

Formyltetrahydroformate biosynthesis (P02743)

4

0.00 %

0.10 %

Fructose galactose metabolism (P02744)

9

0.10 %

0.20 %

GABA-B_receptor_II_signaling (P05731)

30

0.30 %

0.70 %

Gamma-aminobutyric acid synthesis (P04384)

5

0.00 %

0.10 %

GBB_signaling_pathway (P06214)

2

0.00 %

0.00 %

General transcription by RNA polymerase I (P00022)

13

0.10 %

0.30 %

General transcription regulation (P00023)

30

0.30 %

0.70 %

Glutamine glutamate conversion (P02745)

2

0.00 %

0.00 %

Glycolysis (P00024)

18

0.20 %

0.40 %

Gonadotropin releasing hormone receptor pathway (P06664)

185

1.60 %

4.60 %

Hedgehog signaling pathway (P00025)

19

0.20 %

0.50 %

Heme biosynthesis (P02746)

8

0.10 %

0.20 %

Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway (P00026)

103

0.90 %

2.50 %

Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway (P00027)

86

0.70 %

2.10 %

Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction (P00028)

17

0.10 %

0.40 %

Histamine H1 receptor mediated signaling pathway (P04385)

22

0.20 %

0.50 %

Histamine H2 receptor mediated signaling pathway (P04386)

9

0.10 %

0.20 %

Huntington disease (P00029)

112

1.00 %

2.80 %

Hypoxia response via HIF activation (P00030)

21

0.20 %

0.50 %

Inflammation mediated by chemokine and cytokine signaling pathway (P00031)

135

1.20 %

3.30 %

Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade (P00032)

26

0.20 %

0.60 %

Insulin/IGF pathway-protein kinase B signaling cascade (P00033)

30

0.30 %

0.70 %

Integrin signalling pathway (P00034)

135

1.20 %

3.30 %

Interferon-gamma signaling pathway (P00035)

24

0.20 %

0.60 %

Interleukin signaling pathway (P00036)

59

0.50 %

1.50 %

Ionotropic glutamate receptor pathway (P00037)

41

0.40 %

1.00 %

Isoleucine biosynthesis (P02748)

3

0.00 %

0.10 %

JAK/STAT signaling pathway (P00038)

15

0.10 %

0.40 %

Leucine biosynthesis (P02749)

2

0.00 %

0.00 %

Lipoate_biosynthesis (P02750)

2

0.00 %

0.00 %

Mannose metabolism (P02752)

5

0.00 %

0.10 %

Metabotropic glutamate receptor group I pathway (P00041)

19

0.20 %

0.50 %

Metabotropic glutamate receptor group II pathway (P00040)

25

0.20 %

0.60 %

Metabotropic glutamate receptor group III pathway (P00039)

45

0.40 %

1.10 %

Methionine biosynthesis (P02753)

2

0.00 %

0.00 %

Methylcitrate cycle (P02754)

2

0.00 %

0.00 %

Methylmalonyl pathway (P02755)

3

0.00 %

0.10 %

mRNA splicing (P00058)

6

0.10 %

0.10 %

Muscarinic acetylcholine receptor 1 and 3 signaling pathway (P00042)

38

0.30 %

0.90 %

Muscarinic acetylcholine receptor 2 and 4 signaling pathway (P00043)

29

0.30 %

0.70 %

P53 pathway feedback loops 1 (P04392)

5

0.00 %

0.10 %

P53 pathway feedback loops 2 (P04398)

41

0.40 %

1.00 %

Parkinson disease (P00049)

74

0.60 %

1.80 %

PDGF signaling pathway (P00047)

105

0.90 %

2.60 %

Pentose phosphate pathway (P02762)

7

0.10 %

0.20 %

Phenylethylamine degradation (P02766)

1

0.00 %

0.00 %

PI3 kinase pathway (P00048)

40

0.30 %

1.00 %

Plasminogen activating cascade (P00050)

3

0.00 %

0.10 %

PLP biosynthesis (P02759)

1

0.00 %

0.00 %

Proline biosynthesis (P02768)

4

0.00 %

0.10 %

Purine metabolism (P02769)

7

0.10 %

0.20 %

Pyridoxal phosphate salvage pathway (P02770)

1

0.00 %

0.00 %

Pyrimidine Metabolism (P02771)

8

0.10 %

0.20 %

Pyruvate metabolism (P02772)

6

0.10 %

0.10 %

Ras Pathway (P04393)

61

0.50 %

1.50 %

S adenosyl methionine biosynthesis (P02773)

2

0.00 %

0.00 %

Salvage pyrimidine deoxyribonucleotides (P02774)

1

0.00 %

0.00 %

Salvage pyrimidine ribonucleotides (P02775)

6

0.10 %

0.10 %

SCW_signaling_pathway (P06216)

2

0.00 %

0.00 %

Serine glycine biosynthesis (P02776)

5

0.00 %

0.10 %

Succinate to proprionate conversion (P02777)

2

0.00 %

0.00 %

Sulfate assimilation (P02778)

2

0.00 %

0.00 %

Synaptic_vesicle_trafficking (P05734)

24

0.20 %

0.60 %

T cell activation (P00053)

58

0.50 %

1.40 %

TCA cycle (P00051)

9

0.10 %

0.20 %

TGF-beta signaling pathway (P00052)

62

0.50 %

1.50 %

Thiamine metabolism (P02780)

3

0.00 %

0.10 %

Threonine biosynthesis (P02781)

2

0.00 %

0.00 %

Thyrotropin-releasing hormone receptor signaling pathway (P04394)

35

0.30 %

0.90 %

Toll receptor signaling pathway (P00054)

39

0.30 %

1.00 %

Toll_pathway_drosophila (P06217)

1

0.00 %

0.00 %

Transcription regulation by bZIP transcription factor (P00055)

41

0.40 %

1.00 %

Triacylglycerol metabolism (P02782)

1

0.00 %

0.00 %

Tryptophan biosynthesis (P02783)

1

0.00 %

0.00 %

Tyrosine biosynthesis (P02784)

1

0.00 %

0.00 %

Ubiquitin proteasome pathway (P00060)

50

0.40 %

1.20 %

Valine biosynthesis (P02785)

3

0.00 %

0.10 %

Vasopressin synthesis (P04395)

11

0.10 %

0.30 %

VEGF signaling pathway (P00056)

47

0.40 %

1.20 %

Vitamin B6 metabolism (P02787)

3

0.00 %

0.10 %

Vitamin D metabolism and pathway (P04396)

7

0.10 %

0.20 %

Wnt signaling pathway (P00057)

211

1.80 %

5.20 %

Xanthine and guanine salvage pathway (P02788)

4

0.00 %

0.10 %

  1. PANTHER classified 12,731 protein-coding genes with average expression values > 1 CPM by pathway. A total of 4445 pathways were hit