Skip to main content
Fig. 7 | Genome Medicine

Fig. 7

From: Extracting a low-dimensional description of multiple gene expression datasets reveals a potential driver for tumor-associated stroma in ovarian cancer

Fig. 7

a Fisher’s combined p values for survival (y-axis) are shown for the top 300 genes (x-axis) which achieve the most significant survival association in the pan-cancer survival analysis. Module 5 genes are shown in red and module 6 genes are shown in blue. b Fluorescent staining of ovarian tumors from sub-optimally debulked and optimally debulked patients. Each row is a single patient. HOPX is localized to the stroma and does not overlap with E Cadherin positive cancer cells. HOPX does however overlap with CD73, a mesenchymal stem cell marker (c) Left: Expansile growth pattern of high-grade serous carcinoma associated with optimal resectability and low HOPX expression from the TCGA ovarian cancer study. Note high percentage of carcinoma (red arrow) and low percentage of stroma (black arrow). Hematoxylin and Eosin (H&E), 100X. Right: Infiltrative growth pattern of high-grade serous carcinoma associated with low resectability and high HOPX expression from the TCGA ovarian cancer study. Note high percentage of stroma (black arrows) compared with carcinoma (red arrows). H&E, 100X. d A total of 32 genes that are potential targets of HOPX are shown. The purple-colored genes are the potential targets whose expression does not depend on Wnt signaling and the red-colored genes are the potential targets which are downregulated in Hopx −/− mice and further down upon Wnt inhibition in Hopx −/− mice. It is highly likely that the expression of the red-colored genes is driven by both HOPX and Wnt signaling pathway

Back to article page