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Fig. 4 | Genome Medicine

Fig. 4

From: Frequent mutations in acetylation and ubiquitination sites suggest novel driver mechanisms of cancer

Fig. 4

PTM-associated network modules with patient survival correlations. a Analysis of a large protein-protein interaction network with HyperModules reveals protein modules where PTM-specific mutations correlate with reduced patient survival. The top 28 modules with lung and brain cancer mutations are shown. Node size corresponds to the number of PTM mutations per gene. b Survival-linked interaction modules often comprise overlapping sets of genes. The top 30 genes from modules are shown with colors representing modules discovered for different cancer types. c Top module of interest comprises 13 PTM-associated mutations in lung cancer. The module is indicated with an asterisk on panel (a). d Lung cancer patients with mutations in the module of interest have significantly lower survival compared to other lung cancer patients

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