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Fig. 2 | Genome Medicine

Fig. 2

From: Frequent mutations in acetylation and ubiquitination sites suggest novel driver mechanisms of cancer

Fig. 2

Cancer genes with significant mutations in PTM sites. a ActiveDriver predicts cancer driver genes with significant co-occurrence of PTM sites and mutations. Genes are ranked by statistical significance. Known PTM enzymes associated with mutated PTM sites are shown on top of bars. Known cancer genes are highlighted in boldface. Combinatorial mutations shown in green affect lysines that are both acetylated and ubiquitinated. b PTM-associated sequence regions with recurrent cancer mutations (more than five SNVs). Sequence coordinates are shown on top of bars. Known cancer genes are highlighted in boldface. Mutations shown in orange are adjacent to both acetylation and ubiquitination sites. c Cancer mutations in splicing factor subunit SF3B1 (top panel) significantly associate with PTM sites (bottom panel). The ubiquitination site K700 is disrupted by the recurrent cancer mutation K700E

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