Skip to main content
Fig. 4 | Genome Medicine

Fig. 4

From: Reconstruction of gene regulatory networks reveals chromatin remodelers and key transcription factors in tumorigenesis

Fig. 4

Gene regulatory network (GRN) of the BJ stepwise transformation system. a GRN of immortalized BJEL cells. b GRN of transformed BJELM cells. Chromatin remodelers/modulators are represented as diamond-shaped nodes, while other genes, highly connected “hubs”, and “bottlenecks” are represented as circles. The differential expression levels at immortalization and during the transformation steps were colored per node in a heat map format such that the dynamic changes could be visualized. Dashed lines separate the GRN into seven segments corresponding to seven (i to vii) gene co-expression pathways. Functionally related genes are circled under an enriched GO term (DAVID, p < 0.05)

Back to article page