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Table 1 Summary of BRD1 PPIs identified by co-IP mass spectrometry

From: Identification of the BRD1 interaction network and its impact on mental disorder risk

Co-IP MS/MS

Co-IP strengtha

Protein

Uniprot ID

Gene name

Peptide P valueb

BRD1-S

1

BRD1

O95696

Bromodomain-containing protein 1

<1 × 10–10

ZC3H15

Q8WU90

Zinc finger CCCH domain-containing protein 15

<1 × 10–10

DRG1

Q9Y295

Developmentally regulated GTP-binding protein 1

<1 × 10–10

C1QBP

Q07021

Complement component 1 Q sub-component-binding protein

<1 × 10–10

MYST2

O95251

K(lysine) acetyltransferase 7

<1 × 10–10

SUV420H1

Q4FZB7

Suppressor of variegation 4-20 homolog 1

<1 × 10–10

MEAF6

Q9HAF1

MYST/Esa1-associated factor 6

<1 × 10–10

YWHAE

P62258

14-3-3 protein epsilon

5.1 × 10–9

PBRM1

Q86U86

Polybromo-1

2.7 × 10–3

ING4

Q9UNL4

Inhibitor of growth protein 4

4.2 × 10–3

ING5

Q8WYH8

Inhibitor of growth protein 5

1.1 × 10–2

2

NPM1

P06748

Nucleophosmin

<1 × 10–10

YWHAZ

P63104

14-3-3 protein zeta/delta

<1 × 10–10

KPNA1

P52294

Importin subunit alpha-1

<1 × 10–10

KPNA2

P52292

Importin subunit alpha-2

<1 × 10–10

CHD3/CHD4/CHD53

Q14839/Q12873/Q8TDI03

Chromodomain-helicase-DNA-binding protein 3/4/53

<1 × 10–10

YWHAB

P31946

14-3-3 protein beta/alpha

1.6 × 10–7

NAP1L4

Q99733

Nucleosome assembly protein 1-like 4

1.6 × 10–7

CLTC

Q00610

Clathrin heavy chain 1

2.7 × 10–6

DNMT1

P26358

DNA (cytosine-5)-methyltransferase 1

1.6 × 10–5

LYAR

Q9NX58

Cell growth-regulating nucleolar protein

2.1 × 10–5

MRPS14

O60783

28S ribosomal protein S14

5.6 × 10–4

EIF3I

Q13347

Eukaryotic translation initiation factor 3 subunit I

5.2 × 10–3

3

PHB2

Q99623

Prohibitin-2

8.4 × 10–7

NSUN2

Q08J23

NOP2/Sun RNA methyltransferase

7.3 × 10–3

BRD1-L

1

BRD1

O95696

Bromodomain-containing protein 1

<1 × 10–10

YWHAE

P62258

14-3-3 protein epsilon

<1 × 10–10

ZC3H15

Q8WU90

Zinc finger CCCH domain-containing protein 15

<1 × 10–10

DRG1

Q9Y295

Developmentally regulated GTP-binding protein 1

<1 × 10–10

YWHAG

P61981

14-3-3 protein gamma

<1 × 10–10

MEAF6

Q9HAF1

MYST/Esa1-associated factor 6

8.5 × 10–7

ING5

Q8WYH8

Inhibitor of growth protein 5

9.1 × 10–4

PBRM1

Q86U86

Polybromo-1

1.3 × 10–3

MRPS34

O60783

28S ribosomal protein S14

1.5 × 10–3

ING4

Q9UNL4

Inhibitor of growth protein 4

6.2 × 10–3

QSER1

Q2KHR3

Glutamine and serine-rich protein 1

6.4 × 10–3

2

YWHAZ

P63104

14-3-3 protein zeta/delta

<1 × 10–10

CLTC

Q00610

Clathrin heavy chain 1

9.8 × 10–4

3

H3F3A/HIST1H3/HIST3H3c

P84243/P68431/Q16695c

Histone H3.3/Histone H3.1/Histone H3.1 tc

<1 × 10–10

YWHAH

Q04917

14-3-3 protein eta

<1 × 10–10

C1QBP

Q07021

Complement component 1 Q sub-component-binding protein

<1 × 10–10

RPL22L1

Q6P5R6

60S ribosomal protein L22-like

<1 × 10–10

  1. aCo-IP strength, 1: co-IPed 3–4 out of four repeated experiments and sample/control enrichment ratio >3 across four control experiments, 2: co-IPed 3–4 times out of four repeated experiments and sample/control enrichment ratio >2 across four control experiments, 3: co-IPed two out of four repeated experiments and sample/control enrichment ratio >3 across four control experiments (for further details see “Methods”)
  2. bCo-IPed proteins were sorted by the peptide P value (MaxQuant software) within each of three settings for co-IP strength
  3. cIdentified peptides were unique to all listed proteins (encoded by more than one genetically related gene)
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Genome Medicine

ISSN: 1756-994X

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