Identification of key regulators of pancreatic cancer progression through multidimensional systems-level analysis

Table 2 Gene set enrichment analysis of KR-PAM clusters

Name	Size	ES^a	NES^b	Nom P-value^c	FDR q-value^d
IRS1	47	0.814297	2.749994	0	0
E2F3	83	0.538403	2.012985	0	0
ACTN1	197	0.364171	1.523528	0	0.018332
HMGA2	75	0.401607	1.467728	0.0122378	0.020817
NUAK1	26	0.332612	1.002291	0.4466912	0.4542
DLL1	57	−0.90119	−3.20045	0	0
SKI	133	−0.42133	−1.72121	0	0.001876
RASA1	93	−0.19612	−0.75914	0.9367682	0.91951

^a ES Enrichment score showing the maximum deviation from zero based on Kolmogorov-Smirnov statistic
^b NES Normalized enrichment score calculated from a null distribution created from 1000 permutations of phenotype labels
^c Nominal P-value obtained from the null distribution
^d Multiple test corrected P-value
FDR false discovery rate

ISSN: 1756-994X