Fig. 5

Genes under multiple regulatory controls in the PTEN pathway. a PTEN signaling pathway showing differentially expressed genes (red = upregulation, green = downregulation). b Heatmap showing differential expression (log₂Fc) and differential methylation of dysregulated genes involved in the PTEN pathway. The pathway genes interacting with multiple miRNAs are marked (miR-controlled genes; orange stars). Dysregulated genes in the PTEN pathway are shown as rows and columns show differential gene expression, differential methylation and miRNA-interaction, respectively. Relative fold changes are shown with a pseudocolor scale (–1 to 1), with red denoting gene upregulation or hyper-methylation and green denoting gene downregulation or hypo-methylation