Fig. 4
From: Genome dynamics of multidrug-resistant Acinetobacter baumannii during infection and treatment
Selected loci with multiple independent mutations. Genes and gene regions that exhibited a significantly over-representation of mutation frequency are shown. a The pmrCAB genes encode the PmrAB TCRS that is associated with resistance to colistin and one of the target genes (pmrC), that encodes a lipid A phosphoethanolamine transferase. b The adeABC genes encode an RND family efflux pump that is involved in resistance to several classes of antibiotics. The adeRS genes encode a TCRS that regulates adeABC. c A region encoding several genes involved in siderophore biosynthesis. Iron acquisition mediated by siderophores is an important adaptive mechanism in the host environment that is characterized by limited free iron concentrations