Fig. 4From: Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer’s diseaseDifferentially methylated genes (DMRs) are enriched in genes and functional genomic regions with relevance to Alzheimer’s disease pathology. a Summary of gene ontology (GO) term enrichments for DMR-associated genes (n = 475). Significantly enriched terms (q < 0.2) are ranked by estimated fold-enrichment, and colored according to their broader classification (“Molecular Function,” “Biological Process,” and “Cellular Component”). The number of DMR-associated genes (min = 6; max = 268) categorized in each GO term are indicated by circle size. b Heat map of raw P-values associated with enrichment analysis DMRs in regions characterized by individual and combined histone signatures in adult and fetal brain/neuron datasets. Red boxes indicate significant enrichments after correction (corrected P < 0.05). c Significant enrichments of transcription factor binding site motifs within DMR-associated RefSeq gene promoters, based on analysis of datasets curated separately in a medulloblastoma cell line (upper panel) and a lymphoblastoid cell line (lower panel). Motifs are labeled along the x-axis, and are shown in ranked order in each panel according to fold-enrichment. Bonferroni-corrected -log10 P-values are shown as asterisks Back to article page