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Fig. 4 | Genome Medicine

Fig. 4

From: Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer’s disease

Fig. 4

Differentially methylated genes (DMRs) are enriched in genes and functional genomic regions with relevance to Alzheimer’s disease pathology. a Summary of gene ontology (GO) term enrichments for DMR-associated genes (n = 475). Significantly enriched terms (q < 0.2) are ranked by estimated fold-enrichment, and colored according to their broader classification (“Molecular Function,” “Biological Process,” and “Cellular Component”). The number of DMR-associated genes (min = 6; max = 268) categorized in each GO term are indicated by circle size. b Heat map of raw P-values associated with enrichment analysis DMRs in regions characterized by individual and combined histone signatures in adult and fetal brain/neuron datasets. Red boxes indicate significant enrichments after correction (corrected P < 0.05). c Significant enrichments of transcription factor binding site motifs within DMR-associated RefSeq gene promoters, based on analysis of datasets curated separately in a medulloblastoma cell line (upper panel) and a lymphoblastoid cell line (lower panel). Motifs are labeled along the x-axis, and are shown in ranked order in each panel according to fold-enrichment. Bonferroni-corrected -log10 P-values are shown as asterisks

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