Fig. 2

Antigen processing pathways. Top: HLA class I pathway — the endogenous antigen is cleaved by the proteasome into peptides. These peptides are transported into the endoplasmic reticulum (ER) by the TAP and become bound to HLA class I. The HLA–ligand complex is transported in a vesicle to the cell surface and can be recognized by the TCR on CD8⁺ T cells. Bottom: HLA class II pathway — the exogenous antigen is taken up into the cell, digested into peptides and bound to HLA class II in an endosome. The HLA–ligand complex is transported in a vesicle to the cell surface and can be recognized by the TCR on CD4⁺ T cells. HLA human leukocyte antigen, TAP transporter associated with antigen processing, TCR T-cell receptor