Fig. 1

Monocyte-specific psoriasis sub-network. To create the sub-network, the protein products of all psoriasis-associated genes (squares) and their interacting partners (circles) were identified. To improve visual interpretation, psoriasis-associated genes with more than 15 interacting partners were removed. The more overexpressed each gene is in monocytes, the darker the color of the vertex. Edges with larger weights are darker blue and thicker. This sub-network is enriched with high-weight edges (P=0.0001 when genes with more than 15 interacting partners are not removed) that connect many of the disease-associated genes, suggesting that cell-type-specific interactomes may be useful in gene prioritization