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Table 1 Clinical associations with extreme expression

From: Omic personality: implications of stable transcript and methylation profiles for personalized medicine

Person

Loss

Gain

Total

Notable loss

Notable gain

With Axis

Plausible association

Aa

289

55

344

GATA2, ELK1, GSTM4, GPX4

KCNJ2, PTGR2, F8, LMNB1

Low Axis 1

Calcitrol responsive genes with low blood calcium

       

Low Axis 1 with low lymphocyte count

Ab

40

38

78

SLC2A9, ITGB2

TUBB1, CD59

High Axis 7

Diabetic: low sugar transporters with high blood glucose

       

Predicted homocystinurea risk with low glutathione and cysteine-glutathione

       

High tubulin 1 with high platelet count

Ac

38

17

55

ALS2, SMPD1

   

Ad

128

61

189

FUCA1, FUT4, FUT7, CA2

CR2, CD19, CD72, RETN

High Axis 3

Low CA2 with sleep disorder

       

High Axis 3 with B cell activation

       

Protection against type 2 diabetes from resistin, fucosidases

Ce

46

36

82

SPG7, ERCC3, COL5A3, GSTM2

 

High Axis 6

 

Cf

19

41

60

 

TPM1, KCNH2, SIAE, IRAK3

High Axis 5

Negative regulation of immunity with high IL6, IL8

       

High TPM1, KCNH2 with hypertension

Cg

0

1

1

    

Ch

28

65

93

 

GSTP1, MTHFR, TNF, CEBPA

  

Mi

38

80

118

ADSL, GNE, ARMD3, DISC1

CLN6, FTL

Low Axis 6

FTL with high ferritin, total iron capacity

      

High Axis 2

High Axis 2 with high red blood cell count

Mj

17

31

48

F5, FCGR2C, FCGR3A, FCGR3B, LILRA4

CD8A, CCR5, IL2RB, IL12RB2

High Axis 1

Unusual profile predicts aberrant immune signaling

Mk

3

9

12

 

SNTA1, FADS2, COCH

  

Ml

14

12

26

FANCA, SIDT2, SLC22A18

ENC1

Low Axis 3

Four genes are biomarkers of leukemia in the observed direction