Fig. 8

Cytokines and genes with differential effects on psoriasis-specific and non-specific DEGPs (cultured KCs). We identified 153 DEGPs for which RNA-seq and LC-MS/MS indicated elevated mRNA and protein abundance in psoriasis lesions. Nearly all DEGPs were similarly elevated in at least one other skin disease. Nonetheless, all DEGPs can be placed along a continuum separating those that are most psoriasis-specific (similarly altered in few other diseases) from those that are most non-specific (similarly altered in many other diseases). Analysis of microarray data using stratified GSEA revealed different cytokine response profiles and gene functional associations in these two groups (Figs. 6 and 7). The figure shows cytokines and genes that positively regulate expression of psoriasis-specific DEGPs but repress expression of non-specific DEGPs (e.g., IL-17A, STAU, miR-198). Conversely, the figure shows cytokines and genes that repress expression of psoriasis-specific DEGPs but induce expression of non-specific DEGPs (e.g., TNF, IL-1F5, IL-1F8). Arrows denote activation and round-tipped lines denote repression