Fig. 5

Differentially expressed genes/proteins with consistent changes in mRNA/protein abundance in psoriasis lesions versus uninvolved skin. We identified 209 DEGPs with corresponding and significant changes in mRNA and protein abundance in PP skin compared with PN skin (n = 14 patients). The figure lists the 209 DEGPs along with LC-MS/MS-estimated fold changes (PP/PN; horizontal axis). Average NSAF is listed at the base of each bar. Average NSAF was calculated with respect to PP and PN samples, respectively, and the higher of the two average values is listed. The fraction listed for each protein (right) indicates the proportion of skin diseases evaluated in which a corresponding change in mRNA expression was observed (white font indicates relatively psoriasis-specific; green font indicates relatively non-specific). The fraction denominator differs among DEGPs because skin diseases were analyzed using various microarray platforms, with some platforms lacking probes for assaying expression of certain DEGPs