From: Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences
Drug | Sample size | Resistant (%) | Sensitivity (95% CI) | Specificity (95% CI) | Accuracy (95% CI) | China Sen/Spec | Pakistan Sen/Spec | Malawi Sen/Spec | Portugal Sen/Spec | Russia Sen/Spec | Canada Sen/Spec |
---|---|---|---|---|---|---|---|---|---|---|---|
INH | 693 | 305 (44) | 92.8 (89.9-95.7) | 100 (100–100) | 96.8 (95.5-98.1) | 88.0/100 | 100/100 | 92.6/100 | 94.6/100 | 100/100 | -/100 |
RMP | 694 | 264 (38) | 96.2 (93.9-98.5) | 98.1 (96.8-99.4) | 97.4 (96.2-98.5) | 95.7/97.7 | 97.3/100 | 100/98.2 | 96.9/100 | 90.9/90.0 | -/100 |
EMB | 484 | 150 (31) | 88.7 (83.6-93.8) | 81.7 (77.6-85.8) | 83.9 (80.6-87.2) | 83.6/71.3 | 100/42.7 | 100/80 | 85.7/68.1 | 100/80.0 | -/100 |
STR | 487 | 225 (46.2) | 87.1 (82.7-91.5) | 89.7 (86.0-93.4) | 88.5 (85.7-91.3) | 86.8/91.0 | 95.8/44.4 | 61.5/95.6 | 86.8/81.5 | 100/100 | -/100 |
PZA | 307 | 110 (35.8) | 70.9 (62.4-79.4) | 93.9 (90.6-97.2) | 85.7 (81.7-89.6) | NT | 51.3/- | 66.7/94.8 | 80.6/100 | 100/60.0 | -/100 |
ETH | 334 | 155 (46.4) | 73.6 (66.7-80.5) | 93.3 (89.6-97.0) | 84.1 (80.2-88.1) | 38.9/97.3 | 66.7/90.3 | NT | 84.9/84.6 | NT | NT |
MOX | 42 | 10 (23.8) | 60.0 (29.6-90.4) | 68.7 (52.6-84.8) | 66.7 (52.4-80.9) | NT | NT | NT | 83.3/56.2 | 25.0/100 | NT |
OFX | 313 | 117 (37.4) | 85.5 (79.1-91.9) | 94.9 (91.8 · 98.0) | 91.4 (88.3-94.5) | 77.8/95.1 | -/100 | NT | 92.1/93.2 | NT | NT |
AMK | 193 | 76 (39.4) | 82.9 (74.4-91.4) | 98.3 (96.0-100) | 92.2 (88.4-96.0) | NT | 86.5/100 | NT | 79.5/98.2 | NT | NT |
CAP | 358 | 89 (24.9) | 60.7 (50.6-70.8) | 90.7 (87.2-94.2) | 83.2 (79.4-87.1) | 50.0/97.0 | 85.7/21.7 | NT | 57.7/98.0 | 100/91.7 | NT |
KAN | 118 | 118 (37.3) | 87.3 (81.3-93.3) | 93.4 (89.9-96.9) | 91.1 (88.0-94.3) | 71.4/97.0 | 83.8/- | NT | 98.0/88.7 | 80.0/33.3 | NT |
MDR | 693 | 262 (37.8) | 91.2 (87.8-94.6) | 98.4 (97.2-99.6) | 95.8 (94.3-97.3) | 86.3/100 | 97.3/100 | 100/98.2 | 95.8/100 | 90.9/90.0 | -/100 |
XDR | 601 | 54 (9) | 75.9 (64.5-87.3) | 98.4 (97.3-99.5) | 96.3 (94.8-97.8) | 60.9/99.1 | -/100 | -/100 | 96.3/88.9 | 25.0/100 | -/100 |