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Table 3 Prevalence of TET1 , TET2 and TET3 mutations in hematological malignancies and solid tumors

From: TET proteins and the control of cytosine demethylation in cancer

Cancer

TET1 mutation prevalence (%)

TET2 mutation prevalence (%)

TET3 mutation prevalence (%)

Myeloid malignancies

   

MDS

Not reported

6-26 [78,79,165-169]

Not reported

MDS/MPN

   

 CMML (adult)

Not reported

20-58 [78,169-174]

Not reported

MPD

   

 PV

Not reported

6-16 [78,169,170]

Not reported

 ET

Not reported

4-5 [78,169,170]

Not reported

 MF

Not reported

2-17 [78,169,170]

Not reported

CML

Not reported

2-4 [175,176]

Not reported

AML

   

  De novo (adult)

Rare [141]

12-27 [169,170,177-181]

Not reported

  De novo (pediatric)

Not reported

2-4 [182,183]

Not reported

 Secondary AML

Not reported

17-32 [80,85,184,185]

Not reported

Mastocytosis

Not reported

20-29 [87,186]

Not reported

BPDCN

Not reported

25-54 [187-189]

Not reported

Lymphoid malignancies

B-cell lymphoma

   

 DLBCL

Not reported

6-12 [39,81]

Not reported

 MCL

Not reported

0-4 [81,190]

Not reported

 Follicular lymphoma

Not reported

2 [81]

Not reported

CLL

Rare [142]

Not reported

Rare [142]

T cell lymphoma

   

 AITL

Not reported

33-83 [81,86,91,191,192]

Not reported

 PTCL and PTCL, NOS

Not reported

20-49 [81,86,91,191,192]

Rare [90]

T-ALL

Not reported

Not reported

Rare [143]

Solid tumors from

Endometrium

9*

7*

4*

Breast

Rare [106]

Rare [115]

Rare*

Central nervous system

Rare [193]

Rare*

Rare*

Kidney

Rare*

Rare [113]

Rare*

Large intestine

7 [105,137]

4 [105,137]

5 [105,137]

Liver

Rare [194]

Rare*

Rare [195]

Lung

5 [106,114,138]

2 [115,138,139]

Rare [138,139]

Ovary

Rare*

Rare*

Rare [112]

Pancreas

Rare [196,197]

Rare*

Rare*

Prostate

Rare [106,198]

Rare [198,199]

Rare [199]

Skin

Rare [109]

1 [109]

Rare [116]

Stomach

4 [200,201]

Not reported

Rare*

Urinary tract

4 [140]

4*

Rare*

  1. AITL, angioimmunoblastic T cell lymphoma; AML, acute myeloid leukemia; BPDCN, blastic plasmacytoid dendritic cell neoplasm; CLL, chronic lymphocytic leukemia; CML, chronic myeloid leukemia; CMML, chronic myelomonocytic leukemia; DLBCL, diffuse large B cell lymphoma; ET, essential thrombocytosis; FL, follicular lymphoma; MCL, mantle cell lymphoma; MDS, myelodysplastic syndrome; MF, myelofribrosis; MDS/MPN, myelodysplastic syndrome/myeloproliferative neoplasm; MPD, myeloproliferative disorder; PV, polycythemia vera; PTCL, peripheral T cell lymphoma; PTCL,NOS, peripheral T cell lymphoma not otherwise specified; T-ALL, T-cell acute lymphoblastic leukemia; TET, Ten eleven translocation. *COSMIC database. Some mutations listed in this table have not been confirmed as somatic mutations.