From: TET proteins and the control of cytosine demethylation in cancer
Cancer | TET1 mutation prevalence (%) | TET2 mutation prevalence (%) | TET3 mutation prevalence (%) |
---|---|---|---|
Myeloid malignancies | Â | Â | Â |
MDS | Not reported | Not reported | |
MDS/MPN | Â | Â | Â |
 CMML (adult) | Not reported | Not reported | |
MPD | Â | Â | Â |
 PV | Not reported | Not reported | |
 ET | Not reported | Not reported | |
 MF | Not reported | Not reported | |
CML | Not reported | Not reported | |
AML | Â | Â | Â |
  De novo (adult) | Rare [141] | Not reported | |
  De novo (pediatric) | Not reported | Not reported | |
 Secondary AML | Not reported | Not reported | |
Mastocytosis | Not reported | Not reported | |
BPDCN | Not reported | Not reported | |
Lymphoid malignancies | |||
B-cell lymphoma | Â | Â | Â |
 DLBCL | Not reported | Not reported | |
 MCL | Not reported | Not reported | |
 Follicular lymphoma | Not reported | 2 [81] | Not reported |
CLL | Rare [142] | Not reported | Rare [142] |
T cell lymphoma | Â | Â | Â |
 AITL | Not reported | Not reported | |
 PTCL and PTCL, NOS | Not reported | Rare [90] | |
T-ALL | Not reported | Not reported | Rare [143] |
Solid tumors from | |||
Endometrium | 9* | 7* | 4* |
Breast | Rare [106] | Rare [115] | Rare* |
Central nervous system | Rare [193] | Rare* | Rare* |
Kidney | Rare* | Rare [113] | Rare* |
Large intestine | |||
Liver | Rare [194] | Rare* | Rare [195] |
Lung | |||
Ovary | Rare* | Rare* | Rare [112] |
Pancreas | Rare* | Rare* | |
Prostate | Rare [199] | ||
Skin | Rare [109] | 1 [109] | Rare [116] |
Stomach | Not reported | Rare* | |
Urinary tract | 4 [140] | 4* | Rare* |