Figure 8
From: Assessment of patient-derived tumour xenografts (PDXs) as a discovery tool for cancer epigenomics
Model of the effect of PDX-associated methylation changes. For sample numbers n from 5 to 50, n random samples were randomly selected from 2,000 Marmal-aid data sets. Each sample was modified at 11,110 probes by β = 0.51 and a Wilcoxon rank-sum test run between the original n samples and the modified versions. The number of significantly differentially methylated probes (P-value ≤0.05) for each n is plotted against n. The model was run five times and the error bars represent the standard error of the mean at each n.