Figure 5
From: Assessment of patient-derived tumour xenografts (PDXs) as a discovery tool for cancer epigenomics
Assessment of methylation changes in OS and CC PDXs. (a) For each PDX, at each probe, the absolute difference (βPatient - βXenograft) is calculated and binned into 1% methylation difference increments (described by the colour scale); the percentage of probes showing each methylation difference level is shown in the individual plots. (b) Number and percentage of probes in each comparison changing by 0.51 or more, corresponding to all probes going from fully unmethylated to fully methylated and vice versa. (c) The mean percentage of changing probes across all samples at thresholds of 0.51, 0.41, 0.31, and 0.21. Error bars correspond to the standard error of the mean.