From: Virus-host interactomics: new insights and opportunities for antiviral drug discovery
VH PPI databases | ||||
---|---|---|---|---|
Name (reference) | Description | VH interactions | Search date | |
IntAct/MINT [[87]] | Open-data molecular-interaction database populated by data curated either from the literature or from direct data depositions | 5,717 (query performed through IMEx single entry-point) | July 2014 | |
DIP [[88]] | Database that catalogs experimentally determined protein interactions that are either curated or computationally extracted | |||
Uniprot [[89]] | Protein sequence reference database. Among numerous annotations are listed some binary protein interactions quality-filtered from IntAct | |||
VirusMentha [[51]] | Resource that specifically captures and presents interactions between viral and host proteins curated by databases that are part of the IMEx consortium | 5,846 | October 2014 | |
VirHostNet [[52]] | Knowledge base dedicated to literature- and database-curated interactions between viral and human proteins | 3,113 | July 2014 | |
Drug-target databases | ||||
Name (reference) | Description | Drugs | Targets | Search date |
DrugBank [[90]] | High-quality knowledgebase. Provides extensive information on drugs, their mechanisms of action and their associations with targets | 7,739 | 4,092 | July 2014 |
Therapeutic Target Database [[91]] | Conceptually similar to DrugBank. Provides links between primary therapeutic targets and their corresponding drugs | 20,667 | 2,360 | July 2014 |
ChEMBL [[92]] | Large-scale database dedicated to the description of biological activities of numerous chemical entities with drug-like properties, manually curated from the medicinal chemistry literature | 1,359,508 | 9,414 | July 2014 |