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Table 2 Databases of virus-host protein-protein interactions and drug-targets

From: Virus-host interactomics: new insights and opportunities for antiviral drug discovery

VH PPI databases

Name (reference)

Description

VH interactions

Search date

IntAct/MINT [[87]]

Open-data molecular-interaction database populated by data curated either from the literature or from direct data depositions

5,717 (query performed through IMEx single entry-point)

July 2014

DIP [[88]]

Database that catalogs experimentally determined protein interactions that are either curated or computationally extracted

Uniprot [[89]]

Protein sequence reference database. Among numerous annotations are listed some binary protein interactions quality-filtered from IntAct

VirusMentha [[51]]

Resource that specifically captures and presents interactions between viral and host proteins curated by databases that are part of the IMEx consortium

5,846

October 2014

VirHostNet [[52]]

Knowledge base dedicated to literature- and database-curated interactions between viral and human proteins

3,113

July 2014

Drug-target databases

Name (reference)

Description

Drugs

Targets

Search date

DrugBank [[90]]

High-quality knowledgebase. Provides extensive information on drugs, their mechanisms of action and their associations with targets

7,739

4,092

July 2014

Therapeutic Target Database [[91]]

Conceptually similar to DrugBank. Provides links between primary therapeutic targets and their corresponding drugs

20,667

2,360

July 2014

ChEMBL [[92]]

Large-scale database dedicated to the description of biological activities of numerous chemical entities with drug-like properties, manually curated from the medicinal chemistry literature

1,359,508

9,414

July 2014

  1. Abbreviations: IMEx International Molecular Exchange, PPI protein-protein interaction, VH virus-host.