Figure 1

A systems survey of sepsis survival. (A) Schematic representing the different trajectories enrolled subjects might take. X-axis represents time (not to scale), emphasizing the illness progresses from local to systemic infection prior to clinical presentation (t₀). The green line is flat only to distinguish subjects without infection, although these individuals could also have the full spectrum of clinical illness severity. Blue lines represent subjects with sepsis of different severities, all of whom survive at 28 days. This is in contrast to subjects with sepsis who die within 28 days, independent of initial sepsis severity. (B) Analytical plan for the CAPSOD cohort including previously published metabolome and proteome [11]. Metabolomic and proteomic analyses were performed on samples obtained at t₀ and 24 h later. Transcriptomic analysis was performed on samples obtained at t₀.