Author | Reference | Year | Strains sequenced (n) | Stated study purposea | Clinical strains? | Time series? | Method | Report specific genotypic association? |
---|---|---|---|---|---|---|---|---|
Zhang et al. | [26] | 2013 | 161 | Identify drug resistance genes | Yes | No | Phylogenetics and comparison of rates with poisson distribution | Yes; list of genes provided |
Farhat et al. | [15] | 2013 | 124 | Identify drug resistance genes | Yes | No | Phylogenetics and convergence analysis | Yes; list of genes provided |
Lin et al. | [27] | 2013 | 2 | Identify drug resistance genes | Yes | No | Comparison with reference mycobacterial strains | No |
Wu et al. | [28] | 2013 | 4 | Identify Beijing associated pathways | Yes | No | COG enrichment of genes with snps | General pathways rather than individual genes |
Das et al. | [29] | 2013 | 5 | Identify genes related to extrapulmonary TB | Yes | No | COG enrichment of genes with snps | General pathways rather than individual genes |
Ilina et al. | [30] | 2013 | 4 | Identify drug resistance genes | Yes | No | Comparison with reference mycobacterial strains | No |
Abrahams et al. | [31] | 2013 | - | Identify resistance targets(s) for novel imidazole | No | Yes: spontaneous mutants resistant to drug and their sensitive ancestor | Identification of all mutations | Yes qcrb |
Supply et al. | [32] | 2013 | 5 | Identify genes associated with smooth TB phenotype | Yes | No | Comparison with reference mycobacterial strains | General pathways rather than individual genes |
Hartkoorn et al. | [33] | 2012 | - | Identify resistance targets(s) for pyridomycin | No | Yes: spontaneous mutants resistant to drug and their sensitive ancestor | Identification of all mutations | Yes acyl-carrier-protein inha |
G. Sun et al. | [34] | 2012 | 7 | Identify drug resistance genes | Yes | Yes: serial samples from same patient | Identification of all mutations | No; but list of potential candidates with new fixed mutations provided |
Grzegorzewicz et al. | [35] | 2012 | - | Identify resistance targets(s) for novel compound Adamantyl Urea | Yes | Yes: serial samples from the same patient | Identification of all mutations | Yes mmpl3 |
Casali et al. | [36] | 2012 | 59 | Identify drug resistance genes | Yes | No | Phylogenetic tree and parallel evolution and convergence | Yes rpoc |
Tahlan et al. | [37] | 2012 | - | Identify resistance targets(s) for novel compound SQ109 | No | Yes: spontaneous mutants resistant to drug and their sensitive ancestor | Identification of all mutations | Yes mmpl3 |
La Rosa et al. | [38] | 2012 | - | Identify resistance target(s) for 1,5-diarylpyrrole derivative BM212 | No | Yes: spontaneous mutants resistant to drug and their sensitive ancestor | Identification of all mutations | Yes mmpl3 |
Comas et al. | [39] | 2011 | 10 | Identify drug resistance genes | Yes | Yes: serial samples from the same patient | Identification of all mutations in rpoc. Assessment of convergence across different strain pairs | Yes confirmed rpoc |
Manjunatha et al. | [40] | 2006 | - | Identify resistance targets(s) for PA-824 | No | Yes: spontaneous mutants resistant to drug and their sensitive ancestor | Identification of all mutations | Yes Rv3547 |