Figure 5

Presentation styles for WGseq data. (A) Heterozygous reference strain SC5314 (NCBI Sequence Read Archive (SRA) [39], accession SRR868699) showing SNP density, number of SNPs per 5 kb region illustrated in degree of darkness in grey bars; centromere loci are illustrated as an indentation in the chromosome cartoon. (B) Clinical isolate FH5 showing changes in allelic ratio in red and CNV changes including i(5L) in black - all determined relative to the parental strain FH1 (NCBI SRA [40], accession SAMN03144961). (C) Strain FH5 relative to strain FH1 (as in (B)), with complete LOH in red and allelic ratio changes (for example, 3:1 on Chr5L) in green. (D) SC5314-derived lab isolate YJB12746 showing segmental LOH (of both homologs ‘a’ (cyan) and ‘b’ (magenta)) in addition to a segmental aneuploidy on chromosome 4. Chromosome illustrations are as in Figure 2.