Figure 2

Normalization of chromosome-end bias. (A, B) Black bars up- and down-wards from the figure midline represent local copy number estimates, scaled to genome ploidy. Different levels of grey shading in the background indicate local changes in SNP density, with darker grey indicating more SNPs. Detailed interpretations are similar to those described in [25]. (A) Map of data with chromosome end bias present in read-depth CNV estimates for strain YQ2 dataset (from EMBL-EBI BioSamples database [34], accession SAMEA1879786). (B) Corrected CNV estimates for strain YQ2 mapped across all C. albicans chromosomes. (C, D) Raw and corrected normalized read-depth CNV estimates relative to distance from chromosome ends. Red, LOWESS fit curve.