From: Modules, networks and systems medicine for understanding disease and aiding diagnosis
Term | Description |
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Network | A graphical representation of a complex system. For example, in a protein network, proteins are nodes, and interacting proteins are linked by edges |
Disease module | When mapped onto the protein-protein interaction network, disease-associated genes tend to co-localize and form networks of functionally related genes. These networks are referred to as disease modules |
Multilayer disease | A module whose nodes and edges are located across different layers of disease-relevant information. Such layers could include transcription factor networks, genetic variants and even environmental factors |