The `dnet’ approach promotes emerging research on cancer patient survival

Table 1 Comparison of network-based survival analysis tools

	dnet	jActiveModules	Net-Cox	Reactome FI	HyperModules	HotNet
Platform/Language	R	Cytoscape	Matlab^a	Cytoscape	Cytoscape	Python
Operating Systems independent ^b	Yes	Yes	Yes	Yes	Yes	Linux/Unix
Supervised by clinical survival data	Yes	Yes	Yes	No	Yes^c	Yes
Able to adjust for covariables ^d	Yes^e	Yes^e,f	No	No	No	No
Require sophisticated parameter setup	No	Yes	Yes	No	No	Yes
Advanced network visualisation	Yes	Yes	No	Yes	Yes	Yes
Downstream evolution analysis	Yes	No	No	No	No	No
With full documentations	Yes	Yes	No	Yes	Yes	Yes

^aNeeds commercial license.
^bWindows, Mac, Linux/Unix.
^cDoes not support Cox regression.
^dIncludes age, gender and tumour type that are required for cross-tumour survival analysis.
^eIt incorporates this functionality from the package `survival’.
^fCan be extended for this purpose as shown in Figure2.

ISSN: 1756-994X