From: Large hypomethylated blocks as a universal defining epigenetic alteration in human solid tumors
Cancer type | CGIs in testable area (n) | Testable CGIs significantly (q <0.05; deltaM >0.1) hypermethylated (%) | CGIs in blocks (n) | Hypermethylated CGIs in blocks (%) | Odds ratio of CGI being in block and hypermethylated | Pvalue (Chi-squared test) |
---|---|---|---|---|---|---|
Breast | 24,206 | 11 | 316 | 20 | 2.5 | <0.0001 |
Colon | 19,827 | 19 | 3,769 | 30 | 4.1 | <0.0001 |
Lung | 22,661 | 8 | 1,310 | 12 | 2 | <0.0001 |